Humoral factor that specifically regulates prothrombin (factor II) levels (coagulopoietin-II).

Humoral factor that specifically regulates factor X levels in rabbits (coagulopoietin-X).

A heat-stable humoral substance (coagulopoietin-X) is present in rabbits partially depleted of Factor X, which is capable of raising Factor X levels when injected into recipient rabbits. Rabbits were partially depleted of Factor X by slow infusion of a globulin fraction of goat anti-rabbit Factor X antibody. This resulted in the reduction of Factor X to 40--50% of normal at 1 h and 60--70% of n...

the association of coagulation factor v (leiden) and factor ii (prothrombin) mutations with stroke

conclusions the prevalence of both fv and fii variants are population based. iran is an ethnically diverse country. therefore, for a comprehensive analysis of a potential association of fv and/or fii mutations with stroke among iranian population, epidemiological studies could be conducted among different ethnic groups. patients and methods the study population consisted of 153 patients of diff...

Congenital abnormality of the prothrombin molecule (factor II) in four siblings: prothrombin Barcelona.

Prevalence of the Factor V G1691A and the Factor II/prothrombin G20210A gene polymorphisms among Tamilians.

We have investigated the prevalence of the Factor II G20210A and Factor V G1691A single nucleotide polymorphisms (SNPs) in a South Indian-Tamil Nadu population. The SNP genotyping was performed using a polymerase chain reaction (PCR)/restriction fragment length polymorphism analysis and by a recently FDA-approved LightCycler real-time PCR assay. Of 72 samples that were genotyped, 4 (5.5%) patie...

The Association of Coagulation Factor V (Leiden) and Factor II (Prothrombin) Mutations With Stroke

BACKGROUND Epidemiological studies indicate that over the past forty years, the stroke incidence rates has increased. Factors V and II mutations are established genetic-variant risk factors for venous thrombosis; however, their contribution to stroke is a controversial issue. OBJECTIVES This study aimed to investigate the potential association of FV and FII mutations with stroke in an Iranian...